汽车雨挡导流片浮顶式侧抽芯机构注射模设计

介绍了一款汽车雨挡导流片异型塑件两板注射模的结构设计,该模具基于采用常规的滑块抽芯机构及斜顶机构难以实现塑件完全脱模的机构设计困难问题,突破常规设计思路,设计了一种型芯浮顶式侧抽芯机构来实现塑件的自动化注射生产。机构中,在模具开模打开后,通过顶出板及顶杆将塑件和部分成型一同顶出,而后再通过侧边二次顶出机构将塑件从局部型芯上顶出而实现塑件的完全脱模,有效地简化了模具结构设计,降低了模具的加工制造难度,降低了模具的制造成本,模具结构复杂新颖,工作稳定可靠,为异型类塑件的模具结构及机构设计创新设计提供了一个较好的案例借鉴。     

炭黑表面能与甲苯抽出物透光率的关系

选取具有相同比表面积、不同甲苯抽出物透光率的炭黑N134,采用反相色谱测试其表面能,考察炭黑表面能与甲苯抽出物透光率的关系。结果表明:当甲苯抽出物透光率低时,炭黑N134晶体边缘的高能位点被不完全燃烧的原料油或者烃类物质占据,炭黑N134的表面能色散分量低;当甲苯抽出物透光率为77%时,炭黑N134的表面能色散分量为233.6mJ·m~(-2),甚至比甲苯抽出物透过率为92%的炭黑N234低约24%;当甲苯抽出物透光率高于82%时,随着甲苯抽出物透光率的提高,炭黑N134的表面能色散分量呈线性提高;当甲苯透光率为99%时,炭黑N134的表面能色散分量达到511.0 mJ·m~(-2)。炭黑生产企业可通过控制工艺和原材料提高炭黑纯净度,以提高炭黑质量。     

Low complexity quantum private queries protocol

Private information retrieval(PIR) is an important privacy protection issue of secure multi-party computation, but the PIR protocols based on classical cryptography are vulnerable because of new technologies,such as quantum computing and cloud computing. The quantum private queries(QPQ) protocols available, however, has a high complexity and is inefficient in the face of large database. This paper, based on the QKD technology which is mature now, proposes a novel QPQ protocol utilizing the key dilution and auxiliary parameter. Only N quits are required to be sent in the quantum channel to generate the raw key, then the straight k bits in the raw key are added bitwise to dilute the raw key, and a final key is consequently obtained to encrypt the database. By flexible adjusting of auxiliary parameters θ and k, privacy is secured and the query success ratio is improved. Feasibility and performance analyses indicate that the protocol has a high success ratio in first-trial query and is easy to implement, and that the communication complexity of O(N) is achieved.     

一种实用的多数据库量子信息检索协议

针对目前量子私有信息检索不能适用与云存储的多数据库问题,基于现在成熟的量子密钥分发方法,提出了一种适合在多数据库环境下,实用的量子私有信息检索协议。对于不同大小的数据库,协议可通过调节参数θ和k,在保证数据库安全及用户隐私的情况下,完成信息的检索。性能分析结果表明,协议的通信复杂度低,检索成功率高、易于实施。     

基于SCA波形采样读出电子学的CSNS Back-n中子飞行时间测量

中国散裂中子源(CSNS)反角白光中子束线(Back-n)对中子核数据测量和核技术应用等多个领域均有重要意义。为监测其中子束斑轮廓、束流密度及束流能量，研制了由镀硼微网格气体(Micromegas)探测器构成的束流剖面监测装置，并通过测量中子的飞行时间(TOF)来获得能量信息。采用基于开关电容阵列(SCA)专用集成电路(ASIC)的波形采样电子学系统，实现了128路Micromegas探测器阳极条信号的低噪声放大、成形和波形数字化，在现场可编程逻辑门阵列(FPGA)芯片中实现了对信号过阈时间的实时测量，其量程为650 ns～10 ms，电子学时间分辨好于10 ns。在CSNS Back-n上开展实验，成功获得了中子束流剖面及10.65 μs～10 ms范围的飞行时间谱，对应的中子能量范围约为0.16 eV～0.14 MeV。利用钽、钴等吸收体进行了中子共振吸收峰的检验，验证了读出电子学系统的功能及飞行时间测量的正确性。     

CD34⁺ CD38^- subpopulation without CD123 and CD44 is responsible for LSC and correlated with imbalance of immune cell subsets in AML

Acute myeloid leukemia (AML) is regarded as a stem cell disease. However, no one unique marker is expressed on leukemia stem cells (LSC) but not on leukemic blasts nor normal hematopoietic stem cells (HSC). CD34⁺ CD38- with or without CD123 or CD44 subpopulations are immunophenotypically defined as putative LSC fractions in AML. Nevertheless, markers that can be effectively and simply held responsible for the intrinsical heterogeneity of LSC is still unclear. In the present study, we examined the frequency of three different LSC subtypes (CD34⁺ CD38^-, CD34⁺ CD38^- CD123⁺ , CD34⁺ CD38^- CD44⁺ ) in AML at diagnosis. We then validated their prognostic significance on the relevance of spectral features for diagnostic stratification, immune status, induction therapy response, treatment effect maintenance, and long-term survival. In our findings, high proportions of the above three different LSC subtypes were all significantly characterized with low complete remission (CR) rate, high relapse/refractory rate, poor overall survival (OS), frequent FLT3-ITD mutation, the high level of regulatory T cells (Treg) and monocytic myeloid-derived suppressor cells (M-MDSC). However, there was no significant statistical difference in all kinds of other clinical performance among the three different LSC groups. It was demonstrated that CD34⁺ CD38^- subpopulation without CD123 and CD44 might be held responsible for LSC and correlated with an imbalance of immune cell subsets in AML.     

MicroRNA-181a is elevated by 10-hydroxycamptothecin and represses lung carcinoma progression by downregulating FOXP1

Tumor progression is usually characterized by proliferation, migration, and angiogenesis, which is essential for supplying both nutrients and oxygen to the tumor cells. Therefore, targeting angiogenesis has been considered a promising therapeutic strategy for cancer prevention and treatment. In the present study, we demonstrated that in addition to suppressing lung cancer cell proliferation and migration in vitro, 10-hydroxycamptothecin (10-HCPT) is also capable of inhibiting angiogenesis in vivo with a miR-181a-dependent manner. Mechanistically, by upregulating miR-181a, which in turn downregulating FOXP1, 10-HCPT can inhibit the PI3K/Akt/ERK signaling pathwaymediated angiogenesis. Furthermore, reduced levels of miR-181a have been found in both lung cancer cell lines and xenograft with concurrently elevated levels of FOXP1, VEGF, bFGF, and HDGF. Consistent with the findings from the in vitro experiments, miR-181a impairs neovascularization in our xenograft model. In summary, our findings have not only established the anti-oncogenic role of miR-181a in lung cancer angiogenesis but also suggest that 10-HCPT could be a potential therapeutic reagent for lung cancer treatment.     

基于Nvivo12 Plus的劳动教育实践基地评定标准分析

劳动教育是培养人全面发展的重要组成部分,劳动教育实践基地评定标准对劳动教育基地建设有着重要的引领指导作用。本文采用Nvivo12 Plus对7个省市的劳动教育实践基地评定标准进行编码和归类分析,发现已设立的评定标准体系具有强调安全运行是劳动教育实践基地建设的重心、设施完备是劳动教育实践基地建设的中心、育人功能是劳动教育实践基地建设的核心等一些共同特征,但也存在如忽视对教学反馈的评价、内容过于笼统不够全面、忽视基地师资力量评价、各省指标趋同缺乏指向性等问题。为更好地发挥评定标准体系的引领作用,应将教育基地的教学反馈纳入评定标准体系,明确将师资力量构成列为评估指标,增加体验新兴劳动形态的教育内容,在评定标准中彰显地方特性,使劳动教育实践基地评定标准体系更好服务于劳动教育发展的需要。